Denoise manual in LRC removed most of the noise, but made picture soft as well. noise wasn't to bad on the picture, but there was some.
The picture i used foe now was shoot indoors with a Nikon D750 no flash ISO set to Auto -> 4500, tamron dx 18-400mm set to 35mm, f5.6 and speed to 1/320 sec (all manuel except iso). So I updated LRC just now to see how this new DeNoise Ai works.
I have been using Topaz DeNoise AI and Topaz Sharpen AI about a year now and really like the results.